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Fatigue is a complaint that many children with Acute lymphoblastic leukemia (ALL) feel while undergoing chemotherapy and is a multidimensional problem. The condition of fatigue that children continuously feel requires treatment from health workers. To optimize physical exercise interventions, researchers combined physical exercise with Levine theory based on four conservation principles to increase patient activity during treatment. The goal of the study was to provide physical exercise to children with ALL undergoing chemotherapy. The research method is quantitative with Quasy Experimen With Control Group Pre-Test-Post-Test Design. This study sample of ALL children aged 8-13 years who underwent maintenance phase chemotherapy. The sample was taken using consecutive sampling techniques with a total of 22 people. The data collection tool uses the Multidimensional Fatigue Scale questionnaire. The results showed that the average fatigue scale in the pre-test intervention group was 31.18 and post-test 47.64. The pre-test control group was 27.27 and post-test 39.18. The level of fatigue experienced by children decreased (p 0.000) after being given physical exercise walking 5 minutes, six times in 14 days. The involvement of health workers is expected in conducting a comprehensive assessment of fatigue symptoms, and the results of this study can be used as one of the physical exercise interventions in the management of fatigue in children with leukemia.



chemotherapy childhood fatigue leukemia physical exercise

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How to Cite
Apriyanti, A., Mayetti, M., & Deswita, D. (2021). Physical Exercise Reduce Fatigue in Children With Leukemia. Jurnal Ilmu Dan Teknologi Kesehatan, 9(1), 126-138.


    Alibhai, S. M. H. et al. (2015) ‘A phase II exercise randomized controlled trial for patients with acute myeloid leukemia undergoing induction chemotherapy’, Leukemia research, 39(11), pp. 1178–1186. doi:

    Apriany, D. (2016) Asuhan Keperawatan Anak Dengan Keganasan. 1st edn. Edited by N. F. Atif. Bandung: PT Refika Aditama.

    Caru, M. et al. (2019) ‘Childhood acute lymphoblastic leukemia survivors have a substantially lower cardiorespiratory fitness level than healthy Canadians despite a clinically equivalent level of physical activity’, Journal of adolescent and young adult oncology, 8(6), pp. 674–683. doi:

    Dahlia, D., Karim, D. and Damanik, S. R. H. (2019) ‘Gambaran Fatigue Pada Pasien Kanker Post Kemoterapi’, Jurnal Ners Indonesia, 10(1), pp. 80–93. doi:

    Darma, G. S. P., Setiawan, I. G. B. and Widiana, I. G. R. (2021) ‘Pengaruh Aktivitas Fisik Walking Exercise Program (WEP) terhadap Cancer Related Fatigue (CRF) pada Pasien Kanker Payudara di RSUP Sanglah’, Jurnal Bedah Nasional, 5(1), pp. 9–15. doi:

    Goric, L. (2008) A Review of Pediatric Physical Therapy. Edited by J. Tecklin. USA: Taylor & Francis. doi:

    Hermalinda, H. and Novrianda, D. (2016) ‘Skor Fatigue pada Anak dengan Kanker di Ruang Perawatan Anak RSUP dr. M. Djamil Padang’, Jurnal Keperawatan Sriwijaya, 3(1), pp. 40–47.

    Hooke, M. C. and Linder, L. A. (2019) ‘Symptoms in children receiving treatment for cancer—part I: fatigue, sleep disturbance, and nausea/vomiting’, Journal of Pediatric Oncology Nursing, 36(4), pp. 244–261. doi:

    Jitowiyono, S. (2018) Asuhan Keperawatan Pada Pasien Dengan Gangguan Sistem Hematologi. Manado: Pustaka Baru Press.

    Kemenkes RI (2019) Profil Kesehatan Indonesia 2018. Jakarta: Kementerian Kesehatan RI. Available at:

    Komite Penanggulangan Kanker Nasional (2019) Pedoman Strategi & Langkah Aksi Peningkatan Aktivitas Fisik. Jakarta: KPKN.

    Mendri, N. K. and Prayogi, A. S. (2016) Asuhan Keperawatan pada Anak Sakit Bayi Resiko Tinggi. Yogyakarta: Pustaka Baru.

    NCCN (2017) NCCN clinical practice guidelines in oncology. Available at:

    Putri, K. W. (2018) Studi Epidemiologi Profil Klinis dan Laboratorium Pasien Leukemia Limfoblastik Akut Anak di RSUD dr Soetomo. Universitas Airlangga.

    Rekam Medis RSUP dr. M.Djamil (2020) Pengelolaan Data Leukemia. Padang.

    Shrestha, A. D. et al. (2018) ‘Cervical cancer prevalence, incidence and mortality in low and middle income countries: a systematic review’, Asian Pac J Cancer Prev, 19(2), pp. 319–324. doi:

    Stössel, S. et al. (2020) ‘Benefits of exercise training for children and adolescents undergoing cancer treatment: results from the randomized controlled MUCKI trial’, Frontiers in Pediatrics, 8, p. 243. doi:

    Su, H. L. et al. (2018) ‘Assessment of the effects of walking as an exercise intervention for children and adolescents with cancer: A feasibility study’, European Journal of Oncology Nursing, 37, pp. 29–34. doi:

    Sulistini, R. and Putri, P. (2019) ‘Latihan dengan Posisi Duduk Menurunkan Keletihan Penderita Diabetes Mellitus’, in Proceeding Seminar Nasional Keperawatan, pp. 6–9.

    World Health Organization (2018) Global action plan on physical activity 2018-2030: more active people for a healthier world. Geneva: World Health Organization.