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A passive smoker is someone who does not smoke but observes others smoking or is in the same room as the smoker. The influence of cigarettes on platelet count can lead to an increase in atherosclerosis. Inhaling cigarette smoke over a long period of time can lead to an increase in platelet counts as well as platelet aggregation. The purpose of this study was to determine the effect of passive smoking on platelet count in D4 students of Health Analyst. The design used in this study was descriptive analysis with a cross-sectional approach with a total sample of 30. The data analysis used in this study was in the form of the Chi-Square test. The result of this study obtained the number of passive smokers based on gender, age, and length of exposure which was abnormal for as many as 4 students and normal as many for as 26 students. Conclusions in this study there was a relationship between passive smoking based on sex to platelet count with p-value = 0.000, no relationship based on age to platelet count with p-value = 0.603, and no relationship between passive smokers based on length of exposure to platelet count with p-value = 0.475.