jitek

Correlation of Dermatophagoides Pteronyssinus with Serum Der-P Spesific Ige and Igg4

2025-09-30T14:41:00+07:00

Repeated exposure to allergens induces an increase in regulatory T cells that produce interleukin 10 (IL-10) that can lead to B cells switching to immunoglobulin G4 (IgG4). Allergen-specific IgE was used as marker of allergen exposure but was only detected in atopic subjects, not in normal subjects. Therefore, an immunological marker that could be used to scan for exposure is needed. This study was conducted to determine Dermatophagoides pteronyssinus (Der p) density, serum IgE and IgG4-specific Der p levels, and to determine the correlation of Der p density with specific serum levels of IgE and IgG4 Der p in normal and atopic subjects. We calculated the amount and density of Der p in house dust mites (HDM) using the Fain and Hart (1986) method and measured Der p serum levels of IgE and IgG4 using indirect ELISA. We found that the most dominant HDM species was Der p. IgE-specific Der p level in atopic asthma patients were higher than in normal patients (p=0.002), whereas IgG4-specific Der p level in both atopic asthma and normal patients did not exhibit significant differences (p= 0.667). The density of Der p demonstrated a positive correlation with IgG4-specific Der p levels (Spearman r=0.388, p=0.008) compared to IgE-specific Der p.Compared to IgE, the density of Der p demonstrated a correlation with Der p-specific serum IgG4 levels, which means that Der p-specific IgG4 can be used to determine the exposure and accumulation of Der p in the residence of subjects.

Lifestyle Behaviors and Cognitive Outcomes in Physiotherapy Students: Cross-Sectional Study

2025-11-04T11:24:59+07:00

Background: The pervasive use of digital devices, coupled with irregular
sleep and low physical activity, poses potential risks to cognitive outcomes in
university students. Physiotherapy students, whose education demands both
mental and physical engagement, may be particularly vulnerable. Objective:
This study aimed to investigate the integrated effects of smartphone use,
physical activity, and sleep quality on cognitive outcomes among
undergraduate physiotherapy students. Methods: A cross-sectional design
was applied involving 100 first- and second-year physiotherapy students at
Universitas Pembangunan Nasional Veteran Jakarta. Data were collected
through validated self-administered questionnaires, including the Cognitive
Failures Questionnaire (CFQ), International Physical Activity Questionnaire – Short Form (IPAQ-SF), and a Likert-based assessment of smartphone
related lifestyle impact. Descriptive statistics, Pearson correlation, and
multiple regression analyses were performed using SPSS version 26.0.
Results: The findings showed a significant relationship between excessive
digital device use and increased cognitive failures. Poor sleep quality was
also associated with greater cognitive lapses, while higher physical activity
levels correlated positively with better cognitive performance. Regression
analysis indicated that the three lifestyle variables jointly explained a
substantial proportion of the variance in cognitive outcomes. Conclusion:
Digital habits, sleep patterns, and physical activity levels interactively
influence cognitive outcomes in physiotherapy students. Interventions
promoting digital hygiene, adequate sleep, and physical activity may enhance
cognitive resilience and academic performance in this population.

Relationship Between Knowledge and Adherence on Taking Hypertension Medication

2025-10-23T11:01:41+07:00

Hypertension is a chronic condition often called the “silent killer” due to asymptomatic nature and high risk of complications such as stroke, heart failure, and kidney disease when not properly managed. In Indonesia, adherence to antihypertensive medication remains suboptimal, with patient knowledge identified as a key influencing factor. This study aimed to examine the relationship between knowledge level and adherence to antihypertensive medication among patients at Public Health Center X Palembang. A cross-sectional design was employed involving 102 hypertension patients selected through purposive sampling. Data were collected using a structured, validated, and reliable questionnaire assessing knowledge related to hypertension and adherence behaviors using Cronbach alpha. Statistical analysis using the Chi-Square test showed a significant association between knowledge and adherence (p = 0.001), with an Odds Ratio (OR) of 7.091 (95% CI: 2.635–19.084), indicating that patients with good knowledge were over seven times more likely to adhere to medication compared to those with poor knowledge. Effective education improves not only awareness but also self-management skills, such as timely medication intake and handling of side effects. The results suggest that patient education should be a central strategy in primary care, particularly using accessible media like short videos and WhatsApp-based support to reach older populations.

The Effect of Breathing Exercise and Progressive Muscle Relaxation on Improving Sleep Quality in Postmenopausal Women

2025-11-04T13:51:11+07:00

Sleep disturbances are common among menopausal women and negatively
affect quality of life, cognitive function, and emotional well-being. The decline
in estrogen and progesterone during menopause often leads to insomnia, hot
flashes, and anxiety. Non-pharmacological approaches such as Progressive
Muscle Relaxation (PMR) and Breathing Exercise (BE) are considered
effective, yet studies combining both methods remain limited, particularly in
community-based settings. This study aimed to evaluate the effect of combined
PMR and BE on sleep quality in menopausal women within an Integrated
Health Post for the Elderly (Posyandu Lansia) community. A pre
experimental one-group pretest–posttest design was used. Twenty-six
menopausal women, members of the Posyandu Lansia Dahlia II in Surakarta,
Indonesia, were recruited through total sampling. The intervention consisted
of PMR and BE, conducted five times per week for eight weeks. Sleep quality
was measured using the Pittsburgh Sleep Quality Index (PSQI) before and
after the intervention. Data were analyzed using the Wilcoxon Signed-Rank
Test with a significance threshold of p < 0.05. Before the intervention, all
participants reported poor sleep quality with an average PSQI score of 7.54.
After eight weeks, 53.8% of participants showed good sleep quality, with the
average PSQI score decreasing to 6.12. Statistical analysis revealed a
significant difference between pre- and post-intervention scores (p = 0.0001).
In conclusion, the combination of PMR and BE significantly improved sleep
quality in menopausal women and may serve as an effective, low-cost,
community-based health promotion strategy.

The Potential of Cookies Mantul (Calamansi and Bekatul/Rice Bran) as A Healthy Snack to Reduce Emesis Gravidarum in Pregnant Women

2025-11-04T11:42:39+07:00

Nausea and vomiting in pregnancy (NVP) or emesis gravidarum (EG) is
pregnancy discomfort experienced by 70-80% of pregnant women. In early
pregnancy, pregnant women need to avoid chemical drugs as much as
possible because of their potential teratogenic effects, so there is an
increasing trend towards the use of alternative therapies. This research aimed
to investigate the potential and influence of Cookies Mantul (a blend of
calamansi and Bekatul/Rice Bran) on reducing the symptoms of nausea and
vomiting in pregnant women in Trimester 1 (TM 1). This research was a
Quasi-Experiment with a pre-post test control group design. There were 30
participants in this research, with 15 pregnant women in each group for the
intervention and control groups. The data collected using the PUQE-24
Questionnaire and processed statistically using the Mann-Whitney test and
the Wilcoxon test. The results of the statistical test showed that there was an
effect of giving Mantul Cookies on reducing the level of nausea and vomiting
in pregnant women in TM 1, with a p-value = 0.001. The statistical test for
the conttrol group also indicated a significant effect on reducing nausea and
vomiting following the pregnant women’s biscuit (p-value = 0.015). The
results of the statistical test with the Mann-Whitney test showed that there
was no difference in the level of nausea and vomiting in pregnant women after
the intervention between the intervention and control groups, with a p-value
= 0.240.

Risk Factors Associated with The Incidence of Malaria in Mimika Baru District

2025-11-03T13:26:50+07:00

Malaria remains a major health issue in Indonesia, particularly in the eastern
regions, which contribute to about 90% of national cases. Mimika Regency,
especially Mimika Baru District, is one of the high-endemic areas. This study
aimed to identify human and environmental risk factors associated with
malaria incidence. The research, conducted from May to June 2025 in
Mimika Baru District, used a cross-sectional design with 155 respondents
selected through stratified random sampling. Data were analyzed
univariately and bivariately using the chi-square test. Variables included age,
gender, education, occupation, healthcare access, knowledge, ventilation
screen use, mosquito net use, ceiling availability, and the existence of
mosquito breeding sites, resting places, and animal shelters. Results showed
that 83.6% of respondents had contracted malaria in the past year. Factors
significantly associated with malaria incidence were the use of ventilation
screens (p=0.050), mosquito nets (p=0.025), ceilings (p=0.015), breeding
sites (p=0.002), resting places (p=0.015), and animal shelters (p=0.025).
Strengthening malaria prevention and control through public education,
distribution of insecticide-treated nets, and improved environmental
management is recommended.